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desvenlafaxine will improve the amount or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Watch. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by around fifty%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive times right